Molecular genetics of renal cell carcinoma: polybromo 1 and set domain containing 2 genes

Molecular genetics of clear-cell renal cell carcinoma.

Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by frequent inactivation of the VHL gene (infrequently mutated in other tumor types), responsiveness to angiogenesis inhibitors, and resistance to both chemotherapy and conventional radiation therapy. ccRCC tumors exhibit substantial mutation heterogeneity. Recent studies using massively parallel sequencin...

Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma

In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that confers genomic stability. There was enhanced expression of SET domain-containin...

Sarcomatoid Transrormation of Chromophobe Renal Cell Carcinoma

Pneumoviruses: Molecular Genetics and Reverse Genetics

Pneumoviruses are responsible for significant respiratory disease in their hosts and represent a major problemfor human and animal health. Pneumoviruses are members of the family Paramyxoviridae, subfamilyPneumovirinae and the virus particles consist of a negative-sense, nonsegmented RNA genome within a helical nucleocapsid structure enveloped in a lipid membrane derived from the ho...

Molecular genetics of human renal cell tumours.

This review discusses the impact of molecular genetics on the diagnosis and prognosis of renal cell tumours as well as the genetic changes in renal cell tumours associated with von Hippel-Lindau disease and end-stage kidney disease. The use of molecular techniques enables the division of renal cell tumours into genetically and biologically well defined entities. The new classification system di...